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正常组织和器官的放射损伤2细胞和组织放射效应损伤反应的影响因素BT定律早期反应和晚期反应功能性亚单位（FSUs）20.1Relationshipbetweendoseandprobabilityofcomplicationsfordifferenttypesofnormaltissues.CurveArelatestoanormaltissueinwhichthefunctionalsubunitsarenotarrangedseriallyregardlessofwhetheroneorallsubunitsareexposed(i.e.,regardlessoffieldsize).Italsoappliestoanormaltissueinwhichfunctionalsubunitsarearrangedseriallyifonlyonesubunitisexposed(i.e.,ifthefieldissmall).Notethatthecurveisrelativelyshallow(i.e.,theprobabilityofacomplicationrisesrelativelyslowlywithdose).CurvesBandCrefertoatissuewithseriallyarrangedfunctionalsubunits;thecomplicationcurvegetssteeperandmovestolowerdosesasthetreatmentfieldsizeincreases.Forexample,curvesBandC,respectively,relateto4or16functionalsubunitsexposed.(Notethatthepositionofthecurvesinrelationtotheabscissaeisarbitrary,resultingfromtwoassumptions:thatthereisaneffectiveD0of4Gyforasurvivalcurveforcellsexposedtomultipledosesof2Gy,andthat58Gyin2-Gyfractionssterilizes10%ofthefunctionalsubunits.)(AdaptedfromWithersHR,TaylorJMG,MaciejewskiB.Treatmentvolumeandtissuetolerance.IntJRadiatOncolBiolPhys.1988;14:751–759,withpermission.)组织的放射病理学Casarett分类Michalowski分型生长因子14再程放疗的问题晚期损伤的评价LateEffectsofNormalTissue(LENT)conferenceSOMA-subjective,objective,managementcriteriawithanalyticlaboratoryandimagingprocedures.18常见组织的放射反应QUANTEC2021222324造血系统淋巴组织和免疫系统口腔黏膜食管胃肠肺肾肝膀胱上皮神经系统睾丸卵巢女性生殖器血管和脉管系统心脏骨和软骨谢谢！
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