片剂的制备工业药剂PurposeIntroductionEquipmentsandMaterialsProceduresExperimentalInstructionsQuestionsTestreportPurposeIntroductionIntroduction--tablettypesIntroduction--tabletdesignIntroduction--tabletdesignIntroduction--manufacturingprocessesIntroduction--manufacturingprocessesIntroduction--manufacturingprocessesIntroduction--manufacturingprocesses大家有疑问的，可以询问和交流EquipmentsandMaterialsProcedure(2)PreparingprocessesPreparing10%starchpaste:Heatingtheaqueousdispersionofstarch(2gstarchand0、2gtartaricacidin20mLwater)at80℃for15min、Grindingaspirintopassthesieveof80meshes、Mixingaspirinpowderwithstarch、Adding10%starchpastetoprepareadampmass、Screeningthedampmassthroughanylonsieveof18meshesintogranules、Dryingofthewetgranulesat60℃for15min、Drysievingofgranulesthrough16meshes、Addingstarchandtalcumpowdertodrygranuleswithblendinguniformly、pressingthegranulesintotablets、2、Single-punchpress3、Installingofsingle-punchpressInstallingofcoreponentsInstallingofthelowerpunch安装下冲:旋松下冲固定螺钉,转动大皮带轮使下冲芯杆升到最高位置,将下冲插入下冲芯杆得孔中(注意使下冲杆得缺口斜面对准下冲紧固螺钉,并要插到底)最后旋紧下冲固定螺钉。Installingofthelowerpunch安装上冲:旋松上冲紧固螺母,将上冲插入上冲芯杆得孔中,要插到底,旋紧上冲紧固螺母。Installingofthemould安装中模:旋松中模固定螺钉,将中模拿平放入中模台板得孔中,旋紧中模固定螺钉。缓缓转动大皮带轮,调整中模台板得位置,使上冲进入中模孔中,旋紧中模台板固定螺钉。(2)Adjustmentofout-of-tablets出片调整转动大皮带轮使下冲升到最高位置,观察下冲口面就是否与中模平面相齐(或高或低都将影响出片),若不齐则旋松蝶形螺丝,松开齿轮压板转动上调节齿轮,使下冲口面与中模平面相齐,然后将压板按上,旋紧蝶形螺丝。用手转动大皮带轮,空车运转若正常,则可加料试压,进行下一步调整。(3)Adjustmentoftabletweight片重调节旋松蝶形螺丝,松开齿轮压板。转动下调节齿轮向左转使下冲芯杆上升,则充填深度减少(药片重量减轻)。调节好后将轮齿压板按上,旋紧蝶形螺丝。(4)Adjustmentoftablethardness硬度调节旋松连杆锁紧螺母、转动上冲芯杆,向左转使上冲芯杆向下移动,则压力加大,压出得药片硬度增加;反之,硬度降低。调节好后用扳手卡住上冲芯杆下部得六方,将连杆锁紧螺母锁紧。4、Tabletpression压片冲模得安装、调试完成后,即可启动电机试压,检查片重、硬度和表面光洁度等,质量如合格,即可投料批量生产。在生产过程中仍须随时检查药片质量,及时调整。5、QualitycontroloftabletsAftermanufacturingtablets,aseriesoftestsarecarriedouttoassurethattheymeetthespecificationsofpharmacopoeiaorindustrystandards、Thesetestsareaslistedontheright:(1)TabletweightandweightvariationThequantityoffillplacedinthediecavityofatabletpressdeterminestheweightoftheresultin