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血管张力的内源性调节血管活性药物的分类Vasopressors456Vasopressors89Vasodilators11VasodilatorsCCBsActions:AHeart(ver,dil)-Negativeinotropicaction负性肌力作用:excitation-contractiondiscoupling;-Negativechronotropic负性频率作用andslowingconductionactions负性传导作用:inhibitdepolarizationinphases4and0ofslowreactionautonomiccellsCCBsActions:BSmoothmuscle(nif)-Vascularsmoothmuscle:relaxthetoneofartery,especiallycoronaryandcerebralarteries;-Others:relaxsmoothmuscleofbronchus,gastrointestinaltract,ureter输尿管,uterus子宫CCBsCCBsActions:CAnti-atherosclerosis（抗动脉粥样硬化）-AlleviateCa2+overload-Inhibitproliferationofsmoothmusclecellsandproteinproductionofarterialmatrix-Inhibitlipidperoxidation-DecreasecholesterollevelCCBsActions:DErythrocytesandplatelets-Improvemembranestabilityoferythrocytes-InhibitplateletactivationEKidney-IncreasethebloodflowofkidneyCCBsClinicaluses:AAnginapectoris（心绞痛）BArrhythmias（心律失常）:ver,dilCHypertension（高血压）DCerebrovasculardiseases（脑血管病）:nif,nimodipinetransientischemiaattack,cerebralthrombosis（脑血栓形成）,andcerebralembolism（脑栓塞）EOtherdiseases:peripheralvascularspasmodicdisease,arteriosclerosis,migraine（偏头痛）CCBsVasodilators21VasodilatorsVasodilatorsVasodilators26Mainactionsofβreceptorantagonistsonbloodpressure2829PositiveinotropesGlucocorticoides糖皮质激素
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